Send your resume in MS Word format to inquiry@dbashsolutions.com if you are interested in any of the jobs listed below.  Please note: jobs are updated periodically so some jobs may have been recently filled while others may not yet be posted.  Feel free to inquire about other opportunities that may not be listed:


Updated: April 20, 2017


Senior Analytical Chemist, GLP


My client is a growing pharmaceutical company working on RNAi delivery technologies.  They are seeking an experienced formulation scientist to join their chemistry department.  The person in this position will be responsible for developing phase appropriate formulations to support both early and late stage clinical programs.

Location: Madison, WI

Key Responsibilities:

  • Work closely with drug substance and product development teams to develop suitable formulations for the subcutaneous delivery of oligonucleotides.
  • Work with analytical scientists to develop suitable analytical methods to monitor the stability of proposed formulations.
  • Evaluate the proposed formulations and provide recommendations to senior management as to which formulations are appropriate to pursue for toxicology and clinical testing.
  • Communicate on a timely basis and collaborate closely with Arrowhead preferred contract manufacturing organizations (CMOs).
  • Track progress against project plans, generate regular status updates, and communicate progress and issues to management.
  • Be creative and innovation in problem solving.
  • Write sections of regulatory documents.


Requirements:

  • M.S. degree with at least 7 years of experience in the pharmaceutical industry OR a PhD degree with experience at least 5 years of experience in pharmaceutical industry 
  • Working knowledge of common analytical techniques 
  • Ability to independently conduct the analyses and accurately interpret the obtained data
  • Understanding of the drug development process and governing regulations
  • Strong written communication skills


Preferred:

  • Experience working with both small molecule and large molecule drug candidates 
  • Experience developing both early and late stage (through commercialization) formulations 
  • Experience working with regulatory agencies on CMC sections


**Strong benefits package with stock options and relocation are available!

Apply by sending resume (MS Word format) and cover letter highlighting qualifications to inquiry@dbashsolutions.com​  


Senior Scientist, Drug Targeting

My client is agrowing pharmaceutical company.  They are seeking an experienced and highly motivated Senior Scientist to join its drug targeting team. The ideal candidate has experience in drug discovery / lead optimization and a strong understanding of the molecular biology of mammalian gene expression, with core competencies in skills required to correlate changes in expression with disease-modifying activity in vivo


Location: Madison, WI


Key Responsibilities:

  • Responsible for coordinating and advancing the in vitroin vivo & ex vivo molecular pharmacology of novel therapies for metabolic/genetic disease, cancer and other indications.
  • Establishment of in vivo models, mechanism of action studies, and development of bioassays for drug activity.
  • Responsible for experimental design and execution, data analysis and communication.


Requirements:

  • Ph.D. in Biochemistry, Molecular Biology, Cell Biology or a related discipline
  • Minimum of 2 years hands-on experience in early drug development research; industrial (Biotech or Pharma) or translational research experience is preferred
  • Excellent problem solving skills in experimental design, data analysis and interpretation
  • Exceptional verbal and written communication skills
  • Proven ability to translate cutting edge research into drug development programs
  • Ability to coordinate with a team of scientists, while working closely with other research groups and senior managers
  • Ability to remain productive, organized and flexible in a dynamic and fast-paced cross-disciplinary environment
  • Experience with methods and technologies for nucleic acid delivery into mammalian cells, in vitro cell-based assays, immunoassays
  • Experience working with animal models


Preferred:

  • Experience in the development of targeted drug delivery vehicles, including those designed for the delivery of nucleic acids such as RNA


**Strong benefits package with stock options and relocation are available!

Apply by sending resume (MS Word format) and cover letter highlighting qualifications to inquiry@dbashsolutions.com​  


Senior Scientist, Biology

My client is a growing pharmaceutical company.  They are seeking an experienced and highly motivated Senior Scientist to join its drug targeting team. The ideal candidate has experience in cell biology, molecular biology, immunoassay implementation, tissue processing, biochemistry and translating biological functions to drug discovery.  The candidate should enjoy working with a team of scientists in a fast-paced and highly cross-disciplinary environment.  

Location: Madison, WI 

Key Responsibilities:

  • Provide scientific initiatives and technical expertise in experimental design, execution and data analysis.


Requirements:

  • Ph.D. degree in Cell Biology, Molecular Biology, Biochemistry or a related discipline
  • Minimum of two (2) years post-doctoral hands-on experience in early drug development research; industrial (Biotech or Pharma) or translational research experience is preferred
  • Self-motivated, excellent problem solving skills in experimental design and implementation, data analysis and interpretation
  • Exceptional verbal and written communication skills
  • Capable of working with a small team of scientists, while interacting closely with other research groups and senior managers
  • Ability to remain productive, organized and flexible in a fluid and fast-paced environment
  • Experience with methods and technologies for nucleic acid delivery into mammalian cells, in vivo disease model development, in vitro cell-based assays, cell and molecular biology, immunoassays and microscopy.



**Strong benefits package with stock options and relocation are available!

Apply by sending resume (MS Word format) and cover letter highlighting qualifications to inquiry@dbashsolutions.com​    


Senior Medicinal Chemist

My client is a rapidly growing pharmaceutical company.  They are seeking a senior process development scientist to join the oligonucleotide group within the Chemistry Department.  The person in this position will lead a team focused on developing and scaling methods for the manufacturing of oligonucleotides to support toxilogical testing of investigational drug substances. 


Location: Madison, WI 


Key Responsibilities:

  • Design, supervise, and conduct laboratory scale experiments to develop conditions for the manufacturing of oligonucleotides on the hundreds of grams scale.
  • Work closely with our analytical scientists to monitor and understand the impact of process changes on the yield and impurity profile of developmental oligonucleotides.
  • Write procedures for the scale up manufacturing of oligonucleotides following GLP protocols.
  • Contribute to and oversee the GLP manufacturing of oligonucleotides on the hundreds of grams scale.
  • Develop a thorough understanding of both the small and large scale equipment, including scaling factors necessary for success during scale up manufacturing.
  • Prepare comprehensive developmental reports summarizing both laboratory development and manufacturing experiments.
  • Track progress against project plans, generate regular status updates, and communicate progress and issues to management.
  • Be creative and innovation in problem solving.


Requirements:

  • The successful candidate should have a M.S. degree with at least 8 years of experience in the pharmaceutical industry OR a PhD degree with experience at least 4 years of experience in pharmaceutical industry.
  • A thorough understanding of and experience in manufacturing materials under GLP protocols.
  • Must have authorization to work in the U.S.


Preferred Qualifications:

  • Experience working with oligonucleotide manufacturing and with large molecule drug candidates.
  • Understanding of the drug development process and governing regulations.
  • Hands-on experience manufacturing drug products under GMP protocol.
  • Prior experience in contributing to or writing the CMC sections of regulatory documents.


**Strong benefits package with stock options and relocation are available!

Apply by sending resume (MS Word format) and cover letter highlighting qualifications to inquiry@dbashsolutions.com​    



Director, Drug Metabolism & Pharmacokinetics (DMPK)

My client is a rapidly growing pharmaceutical company.  They are looking for smart, creative, experienced professionals who work collaboratively to meet business and scientific challenges in the area of RNA chemistries!  The Director of DMPK reports directly to the VP of Chemistry and Manufacturing.   


Location: Madison, WI 


Key Responsibilities: 

  • Develop and lead overall DMPK/Clinical PK strategies.
  • Manage and build the DMPK function including both in-house resources and CROs.
  • Design, supervise and execute preclinical and clinical ADME/PK studies.
  • Provide discovery project teams with DMPK expertise.
  • Oversee preclinical and clinical PK data analysis and interpretation.
  • Develop clinical DMPK plans to satisfy regulatory expectations.

    

Minimum Qualifications:

  • PhD in Pharmacometrics, Drug Metabolism, Pharmaceutical Science or a related discipline with at least 8 years of industry experience.
  • Deep expertise in all areas of DMPK
  • Strong trouble-shooting skills with hands-on experience
  • Extensive experience with drug development and knowledge of regulatory process
  • Experienced with FDA regulatory guidance and communications
  • Excellent interpersonal, verbal, and written communication skills
  • Must be authorized to work in the U.S.


​Preferred Qualifications:

  • Macromolecule drug metabolism experience preferred


**Strong benefits package with stock options and relocation are available!


Apply by sending resume (MS Word format) and cover letter highlighting qualifications to inquiry@dbashsolutions.com​    



Director, Analytical Development (Chemistry)
My client is a rapidly growing pharmaceutical company.  They are looking for smart, creative, experienced professionals who work collaboratively to meet business and scientific challenges in the area of RNA chemistries!  This candidate would join the Process & Analytical R&D and Manufacturing team.   

Location: Madison, WI 


Key Responsibilities: 

  • Develop robust analytical methods for both large and small molecule drug candidates.
  • Work closely with drug substance and product development teams to determine analytical requirements and develop required analytical methods.
  • Communicate and collaborate where necessary with contract manufacturing organizations.
  • Form strategy and draft analytical portions of regulatory documents.
  • Track progress against project plans, generate regular status updates, and communicate progress and/or issues to management.
  • Supervise research of direct reports.


​Minimum Qualifications:

  • PhD in analytical chemistry with at least 8 years of progressively responsible experience in pharmaceutical or biotech industry (MS with at least 15 years of experience will also be considered).
  • Extensive HPLC and mass spec experience covering a range of separation and detection types.
  • Previous experience in GMP manufacturing and release is required.
  • Experience in writing the analytical portion within CMC section of regulatory documents.
  • Must be authorized to work in the U.S.


Preferred Qualifications

  • Experience in BOTH small and large molecule drug candidates in pharmaceutical industry.
  • Deep understanding of drug development process and governing regulations.
  • Experience interacting with regulatory agencies on analytical issues with CMC section.


**Strong benefits package with stock options and relocation is also available!    

Apply by sending resume (MS Word format) and cover letter highlighting qualifications to inquiry@dbashsolutions.com​